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The main reason for the case 

Different color eyes is the lack of access melanin 

To the eye or a defect in the distribution 

When the dye is non-existent blue eye color output 

The higher the concentration of the dye increased the unit until it becomes brown in color 

It is more common in cats and dogs 

Injury situation of contrasting color eyes may be congenitally 

The result of a gene 

Or acquired as a result of injury or illness 

Or inflammation or the use of eye drops